TUMOR SELECTIVE DRUG DELIVERY BY NEUROTENSIN BRANCHED PEPTIDES
نویسندگان
چکیده
منابع مشابه
Synthesis and biological activity of stable branched neurotensin peptides for tumor targeting.
Receptors for endogenous regulatory peptides, like the neuropeptide neurotensin, are overexpressed in several human cancers and can be targets for peptide-mediated tumor-selective therapy. Peptides, however, have the main drawback of an extremely short half-life in vivo. We showed that neurotensin and other endogenous peptides, when synthesized as dendrimers, retain biological activity and beco...
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periphery, which forms a closed membrane-like structure [3]. When a critical stage is reached dendrimers cannot grow because of steric hindrance. This is sometimes referred to as ‘starburst effect’. In case of PAMAM dendrimers the starburst effect can be observed after the tenth generation [4]. Number of terminal functional groups also increases exponentially with the increased branch density. ...
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ژورنال
عنوان ژورنال: Journal of the Siena Academy of Sciences
سال: 2012
ISSN: 2279-8811,2279-882X
DOI: 10.4081/491